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a549 ace2 tmprss2 cells  (InvivoGen)


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    InvivoGen a549 ace2 tmprss2 cells
    Evaluation of the antiviral activity and toxicity of different compounds of our in-house collection against VSV pseudotyped with BA.2 (A) and BA.4/5 S (B) proteins. VSV pseudotyped with the indicated S proteins was preincubated with the different compounds at 20 μM, followed by the infection of <t>A549-ACE2-TMPRSS2</t> cells. Viral infection was monitored by counting GFP-expressing cells. Toxicity was assessed via the analysis of cell confluency. Bars indicate the mean and SE for n = 3. Individual data points are shown as circles.
    A549 Ace2 Tmprss2 Cells, supplied by InvivoGen, used in various techniques. Bioz Stars score: 96/100, based on 194 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/a549 ace2 tmprss2 cells/product/InvivoGen
    Average 96 stars, based on 194 article reviews
    a549 ace2 tmprss2 cells - by Bioz Stars, 2026-02
    96/100 stars

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    1) Product Images from "A Tetrapodal Tryptophan Derivative with Multiple Exposed Free Carboxylic Acids Blocks Host Cell Entry of Omicron SARS-Cov-2 and Respiratory Syncytial Virus"

    Article Title: A Tetrapodal Tryptophan Derivative with Multiple Exposed Free Carboxylic Acids Blocks Host Cell Entry of Omicron SARS-Cov-2 and Respiratory Syncytial Virus

    Journal: ACS Omega

    doi: 10.1021/acsomega.5c10442

    Evaluation of the antiviral activity and toxicity of different compounds of our in-house collection against VSV pseudotyped with BA.2 (A) and BA.4/5 S (B) proteins. VSV pseudotyped with the indicated S proteins was preincubated with the different compounds at 20 μM, followed by the infection of A549-ACE2-TMPRSS2 cells. Viral infection was monitored by counting GFP-expressing cells. Toxicity was assessed via the analysis of cell confluency. Bars indicate the mean and SE for n = 3. Individual data points are shown as circles.
    Figure Legend Snippet: Evaluation of the antiviral activity and toxicity of different compounds of our in-house collection against VSV pseudotyped with BA.2 (A) and BA.4/5 S (B) proteins. VSV pseudotyped with the indicated S proteins was preincubated with the different compounds at 20 μM, followed by the infection of A549-ACE2-TMPRSS2 cells. Viral infection was monitored by counting GFP-expressing cells. Toxicity was assessed via the analysis of cell confluency. Bars indicate the mean and SE for n = 3. Individual data points are shown as circles.

    Techniques Used: Activity Assay, Infection, Expressing

    Compound 2 blocks the entry of RSV into cells. Time-of-addition experiment with 2 treatment at 4 μM prior to and during infection ( Preincubation and Pre - + Post-incubation ) or following infection ( Post-incubation ) of A549 cells with RSV-A encoding the fluorescent protein mKate2 (see ). Viral infection was quantified at 24 h post infection by examination of mKate2 fluorescence.
    Figure Legend Snippet: Compound 2 blocks the entry of RSV into cells. Time-of-addition experiment with 2 treatment at 4 μM prior to and during infection ( Preincubation and Pre - + Post-incubation ) or following infection ( Post-incubation ) of A549 cells with RSV-A encoding the fluorescent protein mKate2 (see ). Viral infection was quantified at 24 h post infection by examination of mKate2 fluorescence.

    Techniques Used: Infection, Incubation, Fluorescence



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    In vitro antiviral activity of selected compounds. (A) Antiviral activity against VSV pseudotyped with the S protein of Wuhan-Hu-1 and cellular toxicity for the indicated compounds in VeroE6 cells ( n = 3). (B) Virus production of SARS-CoV-2 infection by the indicated compounds at 20 μM or remdesivir (30 μM) in either <t>A549-ACE2</t> or <t>VeroE6-TMPRSS2</t> cells. (C) Antiviral activity of fingolimod against VSV pseudotyped with the indicated S protein ( n = 3). (D) Concentration reducing 50% of viral infection of VSV pseudotyped with the indicated S protein. All data represent the mean and standard error of 3 independent replicates. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 by two-tailed t test on log-transformed data.
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    Image Search Results


    Evaluation of the antiviral activity and toxicity of different compounds of our in-house collection against VSV pseudotyped with BA.2 (A) and BA.4/5 S (B) proteins. VSV pseudotyped with the indicated S proteins was preincubated with the different compounds at 20 μM, followed by the infection of A549-ACE2-TMPRSS2 cells. Viral infection was monitored by counting GFP-expressing cells. Toxicity was assessed via the analysis of cell confluency. Bars indicate the mean and SE for n = 3. Individual data points are shown as circles.

    Journal: ACS Omega

    Article Title: A Tetrapodal Tryptophan Derivative with Multiple Exposed Free Carboxylic Acids Blocks Host Cell Entry of Omicron SARS-Cov-2 and Respiratory Syncytial Virus

    doi: 10.1021/acsomega.5c10442

    Figure Lengend Snippet: Evaluation of the antiviral activity and toxicity of different compounds of our in-house collection against VSV pseudotyped with BA.2 (A) and BA.4/5 S (B) proteins. VSV pseudotyped with the indicated S proteins was preincubated with the different compounds at 20 μM, followed by the infection of A549-ACE2-TMPRSS2 cells. Viral infection was monitored by counting GFP-expressing cells. Toxicity was assessed via the analysis of cell confluency. Bars indicate the mean and SE for n = 3. Individual data points are shown as circles.

    Article Snippet: A549-ACE2-TMPRSS2 cells (catalog a549-hace2tpsa) were purchased from InVivoGen.

    Techniques: Activity Assay, Infection, Expressing

    Compound 2 blocks the entry of RSV into cells. Time-of-addition experiment with 2 treatment at 4 μM prior to and during infection ( Preincubation and Pre - + Post-incubation ) or following infection ( Post-incubation ) of A549 cells with RSV-A encoding the fluorescent protein mKate2 (see ). Viral infection was quantified at 24 h post infection by examination of mKate2 fluorescence.

    Journal: ACS Omega

    Article Title: A Tetrapodal Tryptophan Derivative with Multiple Exposed Free Carboxylic Acids Blocks Host Cell Entry of Omicron SARS-Cov-2 and Respiratory Syncytial Virus

    doi: 10.1021/acsomega.5c10442

    Figure Lengend Snippet: Compound 2 blocks the entry of RSV into cells. Time-of-addition experiment with 2 treatment at 4 μM prior to and during infection ( Preincubation and Pre - + Post-incubation ) or following infection ( Post-incubation ) of A549 cells with RSV-A encoding the fluorescent protein mKate2 (see ). Viral infection was quantified at 24 h post infection by examination of mKate2 fluorescence.

    Article Snippet: A549-ACE2-TMPRSS2 cells (catalog a549-hace2tpsa) were purchased from InVivoGen.

    Techniques: Infection, Incubation, Fluorescence

    In vitro antiviral activity of selected compounds. (A) Antiviral activity against VSV pseudotyped with the S protein of Wuhan-Hu-1 and cellular toxicity for the indicated compounds in VeroE6 cells ( n = 3). (B) Virus production of SARS-CoV-2 infection by the indicated compounds at 20 μM or remdesivir (30 μM) in either A549-ACE2 or VeroE6-TMPRSS2 cells. (C) Antiviral activity of fingolimod against VSV pseudotyped with the indicated S protein ( n = 3). (D) Concentration reducing 50% of viral infection of VSV pseudotyped with the indicated S protein. All data represent the mean and standard error of 3 independent replicates. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 by two-tailed t test on log-transformed data.

    Journal: ACS Omega

    Article Title: Exploring SARS-CoV‑2 Spike RBD Pockets as Targets for Generic Drugs: A Combined Computational, Biophysical, and Biological Approach

    doi: 10.1021/acsomega.5c05175

    Figure Lengend Snippet: In vitro antiviral activity of selected compounds. (A) Antiviral activity against VSV pseudotyped with the S protein of Wuhan-Hu-1 and cellular toxicity for the indicated compounds in VeroE6 cells ( n = 3). (B) Virus production of SARS-CoV-2 infection by the indicated compounds at 20 μM or remdesivir (30 μM) in either A549-ACE2 or VeroE6-TMPRSS2 cells. (C) Antiviral activity of fingolimod against VSV pseudotyped with the indicated S protein ( n = 3). (D) Concentration reducing 50% of viral infection of VSV pseudotyped with the indicated S protein. All data represent the mean and standard error of 3 independent replicates. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 by two-tailed t test on log-transformed data.

    Article Snippet: VeroE6-TMPRSS2 (Catalog No. JCRB1819, Japanese Collection of Research Bioresources), VeroE6 (kindly provided by Dr. Luis Enjuanes, CNB–CSIC, Spain), and A549-Ace2-TMPRSS2 (Catalog No. a549-hace2tpsa, Invivogen) were cultured in DMEM high glucose, with glutamine, 10% FBS, and 1% penicillin/streptomycin.

    Techniques: In Vitro, Activity Assay, Virus, Infection, Concentration Assay, Two Tailed Test, Transformation Assay