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human ace2 gene  (InvivoGen)


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    InvivoGen human ace2 gene
    Human Ace2 Gene, supplied by InvivoGen, used in various techniques. Bioz Stars score: 96/100, based on 155 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/a549+ace2+tmprss2+cells/A549-hACE2-TMPRSS2+Cells/pm41666538-78-6-14
    Average 96 stars, based on 155 article reviews
    human ace2 gene - by Bioz Stars, 2026-09
    96/100 stars

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    Cell Culture:

    Article Title: A coronavirus assembly inhibitor that targets the viral membrane protein
    Article Snippet: .. The A549 ACE2+TMPRSS2 cells (a human lung carcinoma cell line overexpressing human ACE2 and human TMPRSS2 receptors), used for antiviral studies, were from InvivoGen (a549d-cov2r, A549-Dual hACE2-TMPRSS2 cells) and were cultured in DMEM supplemented with 10% v/v heat-inactivated FBS, 300 μg ml −1 hygromycin, 0.5 μg ml −1 puromycin and 10 μg ml −1 blasticidin. .. A549 ACE2+TMPRSS2 cells, used for subcellular studies, were generated in-house from A549 obtained from ATCC (CCL-185), using lentiviral transduction with pWPI vectors encoding ACE2 (selected using 500 μg ml −1 geneticin) and TMPRSS2 (selected using 1 μg ml −1 puromycin) under EF1alpha promotor control.

    Article Title: Immunogenicity and Efficacy of Monovalent and Bivalent Formulations of a Virus-Like Particle Vaccine against SARS-CoV-2
    Article Snippet: 293T cells (ATCC, CRL-3216) were maintained in Dulbecco’s Modified Eagles Medium (DMEM) (ATCC, 30-2002) supplemented with 10% heat-inactivated fetal bovine serum (FBS), 2 mM L-Glutamine and 1× penicillin/streptomycin (100 U penicillin and 100 μg streptomycin per mL). .. A549-ACE2-TMPRSS2 cells (InvivoGen) were cultured in DMEM (Gibco, 11995065) supplemented with 10% heat-inactivated FBS and 1× penicillin/streptomycin. ..

    other:

    Article Title: HLA-C-derived peptide MH-1 as an early-stage intervention against SARS-CoV-2 infection.
    Article Snippet: A549-ACE2-TMPRSS2 cells (designated as A549-OE) were purchased from InvivoGen (#20K23-NJ, San Diego, California) and

    Article Title: HLA-C–derived peptide MH-1 as an early-stage intervention against SARS-CoV-2 infection
    Article Snippet: A549-ACE2-TMPRSS2 cells (designated as A549-OE) were purchased from InvivoGen (#20K23-NJ, San Diego, California) and maintained in DMEM with 10% heat-inactivated fetal bovine serum (FBS), 1% Penicillin/streptomycin (PS), 0.5 mg/mL of Puromycin and 300 mg/mL of Hygromycin B (InvivoGen) in 5% CO 2 at 37°C.

    Modification:

    Article Title: Discovery of SARS-CoV-2 Nsp14-Methyltransferase (MTase) Inhibitors by Harnessing Scaffold-Centric Exploration of the Ultra Large Chemical Space
    Article Snippet: The global impact of SARS-CoV-2 underscores the need for antiviral treatments beyond vaccines.. This study targets Nsp14-MTase, a viral protein essential for replication.. Initial quantitative high-throughput screening (qHTS) of ∼15,000 compounds from the selected NCATS in-house libraries identified 135 active hit molecules, reflecting a hit-rate of 1.04%.

    Incubation:

    Article Title: Discovery of SARS-CoV-2 Nsp14-Methyltransferase (MTase) Inhibitors by Harnessing Scaffold-Centric Exploration of the Ultra Large Chemical Space
    Article Snippet: The global impact of SARS-CoV-2 underscores the need for antiviral treatments beyond vaccines.. This study targets Nsp14-MTase, a viral protein essential for replication.. Initial quantitative high-throughput screening (qHTS) of ∼15,000 compounds from the selected NCATS in-house libraries identified 135 active hit molecules, reflecting a hit-rate of 1.04%.

    Virus:

    Article Title: C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein
    Article Snippet: .. Pseudotyped vesicular stomatitis virus (VSV) carrying a codon-optimized gene for the S protein of the Wuhan-Hu-1 or the Omicron BA.1 variant SARS-CoV-2 strain and encoding both GFP and firefly luciferase was produced and tittered on Vero cells or A549-Ace2-TMPRSS2 cells (InVivoGen, a549-hace2tpsa) as previously described. ..

    Variant Assay:

    Article Title: C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein
    Article Snippet: .. Pseudotyped vesicular stomatitis virus (VSV) carrying a codon-optimized gene for the S protein of the Wuhan-Hu-1 or the Omicron BA.1 variant SARS-CoV-2 strain and encoding both GFP and firefly luciferase was produced and tittered on Vero cells or A549-Ace2-TMPRSS2 cells (InVivoGen, a549-hace2tpsa) as previously described. ..

    Luciferase:

    Article Title: C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein
    Article Snippet: .. Pseudotyped vesicular stomatitis virus (VSV) carrying a codon-optimized gene for the S protein of the Wuhan-Hu-1 or the Omicron BA.1 variant SARS-CoV-2 strain and encoding both GFP and firefly luciferase was produced and tittered on Vero cells or A549-Ace2-TMPRSS2 cells (InVivoGen, a549-hace2tpsa) as previously described. ..

    Produced:

    Article Title: C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein
    Article Snippet: .. Pseudotyped vesicular stomatitis virus (VSV) carrying a codon-optimized gene for the S protein of the Wuhan-Hu-1 or the Omicron BA.1 variant SARS-CoV-2 strain and encoding both GFP and firefly luciferase was produced and tittered on Vero cells or A549-Ace2-TMPRSS2 cells (InVivoGen, a549-hace2tpsa) as previously described. ..



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    Image Search Results


    In vitro antiviral activity of selected compounds. (A) Antiviral activity against VSV pseudotyped with the S protein of Wuhan-Hu-1 and cellular toxicity for the indicated compounds in VeroE6 cells ( n = 3). (B) Virus production of SARS-CoV-2 infection by the indicated compounds at 20 μM or remdesivir (30 μM) in either A549-ACE2 or VeroE6-TMPRSS2 cells. (C) Antiviral activity of fingolimod against VSV pseudotyped with the indicated S protein ( n = 3). (D) Concentration reducing 50% of viral infection of VSV pseudotyped with the indicated S protein. All data represent the mean and standard error of 3 independent replicates. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 by two-tailed t test on log-transformed data.

    Journal: ACS Omega

    Article Title: Exploring SARS-CoV‑2 Spike RBD Pockets as Targets for Generic Drugs: A Combined Computational, Biophysical, and Biological Approach

    doi: 10.1021/acsomega.5c05175

    Figure Lengend Snippet: In vitro antiviral activity of selected compounds. (A) Antiviral activity against VSV pseudotyped with the S protein of Wuhan-Hu-1 and cellular toxicity for the indicated compounds in VeroE6 cells ( n = 3). (B) Virus production of SARS-CoV-2 infection by the indicated compounds at 20 μM or remdesivir (30 μM) in either A549-ACE2 or VeroE6-TMPRSS2 cells. (C) Antiviral activity of fingolimod against VSV pseudotyped with the indicated S protein ( n = 3). (D) Concentration reducing 50% of viral infection of VSV pseudotyped with the indicated S protein. All data represent the mean and standard error of 3 independent replicates. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 by two-tailed t test on log-transformed data.

    Article Snippet: VeroE6-TMPRSS2 (Catalog No. JCRB1819, Japanese Collection of Research Bioresources), VeroE6 (kindly provided by Dr. Luis Enjuanes, CNB–CSIC, Spain), and A549-Ace2-TMPRSS2 (Catalog No. a549-hace2tpsa, Invivogen) were cultured in DMEM high glucose, with glutamine, 10% FBS, and 1% penicillin/streptomycin.

    Techniques: In Vitro, Activity Assay, Virus, Infection, Concentration Assay, Two Tailed Test, Transformation Assay